For research use only. Not for therapeutic Use.
AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2].
AM 374 (0-9 nM) inhibits anandamide breakdown in N18TG2 cells[1].
AM 374 (20 μg; i.c.v., once) shows no effect on FR5 lever pressing but reduces lever pressing combined with IP injections of anandamide[2].
| Catalog Number | I012834 |
| CAS Number | 86855-26-7 |
| Synonyms | hexadecane-1-sulfonyl fluoride |
| Molecular Formula | C16H33FO2S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(17,18)19/h2-16H2,1H3 |
| InChIKey | QIVFMUVBIHIZAM-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCS(=O)(=O)F |
| Reference | [1]. Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21. [2]. Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004 Jan 9;74(8):1001-11. |
