For research use only. Not for therapeutic Use.
AM404 is an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its re-<wbr></wbr>uptake into presynaptic neurons. AM404 selectively inhibits the carrier-<wbr></wbr>mediated transport of AEA without affecting anandamide hydrolysis. It inhibits the transport of AEA with an IC<sub>50</sub> of 1 µM in rat neurons and 5 µM in rat astrocytes. In <em>in vivo</em> models, AM404 enhances and prolongs exogenous AEA-<wbr></wbr>induced analgesia at a dose of 10 mg/kg.
| Catalog Number | R011408 |
| CAS Number | 183718-77-6 |
| Synonyms | (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; (all-Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; |
| Molecular Formula | C26H37NO2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide |
| InChI | InChI=1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6-,10-9-,13-12-,16-15- |
| InChIKey | IJBZOOZRAXHERC-DOFZRALJSA-N |
| SMILES | CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)O |
