AM-92016 hydrochloride

• CAT Number: I010315
• CAS Number: 133229-11-5
• Molecular Formula: C19H25Cl3N2O4S
• Molecular Weight: 483.84
• Purity: ≥95%
• Synonyms: N-[4-[3-[2-(3,4-dichlorophenyl)ethyl-methylamino]-2-hydroxypropoxy]phenyl]methanesulfonamide;hydrochloride
• InChI: InChI=1S/C19H24Cl2N2O4S.ClH/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26;/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3;1H
• InChIKey: TXOARFPCQOBODS-UHFFFAOYSA-N
• SMILES: CN(CCC1=CC(=C(C=C1)Cl)Cl)CC(COC2=CC=C(C=C2)NS(=O)(=O)C)O.Cl

AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse[1].

Reference

[1]. ConnorsSP,etal.Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbitventricular cells. Br J Pharmacol. 1992 Aug;106(4):958-65.
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