For research use only. Not for therapeutic Use.
Oleoyl ethanolamide (OEA) is an endogenous agonist for proliferator-<wbr></wbr>activated receptor α (PPARα) that suppresses food intake, promotes lipolysis, and reduces weight gain in rodents. The biological effects of OEA are terminated by fatty-<wbr></wbr>acid amide hydrolase and N-<wbr></wbr>acylethanolamine-<wbr></wbr>hydrolyzing acid amidase. AM3102 is an OEA analog that stimulates PPARα transcriptional activity with an EC<sub>50</sub> value of 100 nM and prolongs feeding latency in rodents with an ED<sub>50</sub> value of 2.4 mg/kg. It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARα and reducing food intake in free-<wbr></wbr>feeding rats. AM3102 demonstrates weak affinity for the central cannabinoid (CB<sub>1</sub>) and peripheral cannabinoid (CB<sub>2</sub>) receptors with K<sub>i</sub> values of 33 and 26 µM, respectively.
| Catalog Number | R064466 |
| CAS Number | 213182-22-0 |
| Synonyms | KDS-5104 |
| Molecular Formula | C21H41NO2 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Storage | -20°C |
| IUPAC Name | (Z)-N-[(2R)-1-hydroxypropan-2-yl]octadec-9-enamide |
| InChI | InChI=1S/C21H41NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21(24)22-20(2)19-23/h10-11,20,23H,3-9,12-19H2,1-2H3,(H,22,24)/b11-10-/t20-/m1/s1 |
| InChIKey | IPVYNYWIRWMRHH-JPMGXVIASA-N |
| SMILES | CCCCCCCCC=CCCCCCCCC(=O)NC(C)CO |
| Reference | 1.Astarita, G.,Di Giacomo, B.,Gaetani, S., et al. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. Journal of Pharmacology and Experimental Therapeutics 318(2), 563-570 (2006). |
