For research use only. Not for therapeutic Use.
Amantadine（Cat No.:I001948）is an antiviral and antiparkinsonian drug known for its dual mechanism of action. Initially developed to prevent and treat influenza A, it inhibits the viral M2 protein, disrupting viral replication. Amantadine is also used to manage symptoms of Parkinson’s disease and other movement disorders, as it enhances dopamine release and blocks NMDA receptors, improving motor function and reducing rigidity. Its neuroprotective properties have led to studies exploring its potential in traumatic brain injury and neurodegenerative diseases, making Amantadine valuable in both infectious disease and neurological research.
| Catalog Number | I001948 |
| CAS Number | 768-94-5 |
| Synonyms | 1 Aminoadamantane; 1-Aminoadamantane; Adamantylamine; Adekin; AL, Amantadin; Aliud Brand of Amantadine Sulfate; Aman; Amanta;adamantan-1-amine |
| Molecular Formula | C10H17N |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | Room temperature |
| IUPAC Name | adamantan-1-amine |
| InChI | InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2 |
| InChIKey | DKNWSYNQZKUICI-UHFFFAOYSA-N |
| SMILES | C1C2CC3CC1CC(C2)(C3)N |
| Reference | </br>1:The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status. Fryml LD, Williams KR, Pelic CG, Fox J, Sahlem G, Robert S, Revuelta GJ, Short EB.J Psychiatr Pract. 2017 May;23(3):191-199. doi: 10.1097/PRA.0000000000000237. PMID: 28492457 </br>2:Development of a competitive immunochromatographic assay for the sensitive detection of amantadine in chicken muscle. Wu S, Zhu F, Hu L, Xia J, Xu G, Liu D, Guo Q, Luo K, Lai W.Food Chem. 2017 Oct 1;232:770-776. doi: 10.1016/j.foodchem.2017.04.058. Epub 2017 Apr 12. PMID: 28490139 </br>3:Molecular analysis of amantadine-resistant influenza A (H1N1 pdm09) virus isolated from slum dwellers of Dhaka, Bangladesh. Rahman M, Hoque SA, Islam MA, Rahman SR.Virus Genes. 2017 Jun;53(3):377-385. doi: 10.1007/s11262-017-1447-x. Epub 2017 Apr 11. PMID: 28401407 </br>4:Amantadine for Antipsychotic-Related Weight Gain: Meta-Analysis of Randomized Placebo-Controlled Trials. Zheng W, Wang S, Ungvari GS, Ng CH, Yang XH, Gu YH, Li M, Xiang YQ, Xiang YT.J Clin Psychopharmacol. 2017 Jun;37(3):341-346. doi: 10.1097/JCP.0000000000000598. PMID: 28383359 </br>5:Dispersive micro solid phase extraction of amantadine, rimantadine and memantine in chicken muscle with magnetic cation exchange polymer. Chen D, Miao H, Zhao Y, Wu Y.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 15;1051:92-96. doi: 10.1016/j.jchromb.2017.03.005. Epub 2017 Mar 10. PMID: 28334651 </br>6:Study on the abuse of amantadine in tissues of broiler chickens by HPLC-MS/MS. You X, Yang S, Zhao J, Zhang Y, Zhao L, Cheng Y, Hou C, Xu Z.J Vet Pharmacol Ther. 2017 Jan 30. doi: 10.1111/jvp.12388. [Epub ahead of print] PMID: 28133761 </br>7:Simultaneous determination of amantadine, rimantadine, and memantine in processed products, chicken tissues, and eggs by liquid chromatography with tandem mass spectrometry. Tsuruoka Y, Nakajima T, Kanda M, Hayashi H, Matsushima Y, Yoshikawa S, Nagata M, Koike H, Nagano C, Sekimura K, Hashimoto T, Takano I, Shindo T.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15;1044-1045:142-148. doi: 10.1016/j.jchromb.2017.01.014. Epub 2017 Jan 11. PMID: 28107701 </br>8:Binding and Proton Blockage by Amantadine Variants of the Influenza M2<sub>WT</sub> and M2<sub>S31N</sub> Explained. Tzitzoglaki C, Wright A, Freudenberger K, Hoffmann A, Tietjen I, Stylianakis I, Kolarov F, Fedida D, Schmidtke M, Gauglitz G, Cross TA, Kolocouris A.J Med Chem. 2017 Mar 9;60(5):1716-1733. doi: 10.1021/acs.jmedchem.6b01115. Epub 2017 Feb 15. PMID: 28107633 </br>9:A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. Nolte E, Wach S, Silva IT, Lukat S, Ekici AB, Munkert J, Müller-Uri F, Kreis W, Oliveira Simões CM, Vera J, Wullich B, Taubert H, Lai X.Oncotarget. 2017 Feb 14;8(7):11676-11691. doi: 10.18632/oncotarget.14644. PMID: 28099931 Free PMC Article</br>10:An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Hu Y, Musharrafieh R, Ma C, Zhang J, Smee DF, DeGrado WF, Wang J.Antiviral Res. 2017 Apr;140:45-54. doi: 10.1016/j.antiviral.2017.01.006. Epub 2017 Jan 10. PMID: 28087313 |
