For research use only. Not for therapeutic Use.
Amcinonide (Cat.No:I003824) is a glucocorticoid receptor agonist used in the treatment of inflammatory skin conditions such as psoriasis, eczema, and dermatitis. It works by suppressing the immune system and reducing inflammation. Amcinonide is applied topically and is available in various formulations such as creams, ointments, and lotions. Its CAS number is 51022-69-6.
| Catalog Number | I003824 |
| CAS Number | 51022-69-6 |
| Molecular Formula | C28H35FO7 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 3.38 nM [1] |
| IUPAC Name | [2-[(1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-9,13-dimethyl-16-oxospiro[5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-diene-6,1'-cyclopentane]-8-yl]-2-oxoethyl] acetate |
| InChI | InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19?,20-,21?,23+,24?,25?,27?,28?/m0/s1 |
| InChIKey | ILKJAFIWWBXGDU-UVHNLHPKSA-N |
| SMILES | CC(OCC(C([C@@](O1)([H])C[C@@]2([H])C3CCC4=CC5=O)(C2(C)CC(O)C3(F)C4(C)C=C5)OC61CCCC6)=O)=O |
| Reference | </br>1:Exacerbation of allergic contact dermatitis from amcinonide triggered by patch testing. Sasseville D.Contact Dermatitis. 2001 Oct;45(4):232-3. No abstract available. PMID: 11683835 </br>2:Contact dermatitis from budesonide in a nasal spray without cross-reactivity to amcinonide. Gamboa PM, Jáuregui I, Antépara I.Contact Dermatitis. 1991 Mar;24(3):227-8. No abstract available. PMID: 1831101 </br>3:Allergic contact dermatitis due to amcinonide. Hayakawa R, Matsunaga K, Suzuki M, Ogino Y, Arisu K, Arima Y, Hirose O.Contact Dermatitis. 1990 Jul;23(1):49-50. No abstract available. PMID: 2144811 </br>4:Investigations on the development and regression of corticosteroid-induced thinning of the skin in various parts of the human body during and after topical application of amcinonide. Lubach D, Grüter H, Behl M, Nagel C.Dermatologica. 1989;178(2):93-7. PMID: 2924987 </br>5:Contact dermatitis due to amcinonide. Sasaki E, Shinya M, Fujioka M, Sato M, Hata M, Yajima J, Hattori S, Honda M.Contact Dermatitis. 1988 Jan;18(1):61-2. No abstract available. Erratum in: Contact Dermatitis 1988 May;18(5):324. PMID: 2964991 </br>6:Contact dermatitis from amcinonide. Hayakawa R, Matsunaga K, Suzuki M, Hosokawa K.Contact Dermatitis. 1987 Jan;16(1):48-9. No abstract available. PMID: 3816214 </br>7:A comparative study of amcinonide and halcinonide 0.1% ointments in the treatment of psoriasis. Millikan LE, Mroczkowski TF.Int J Dermatol. 1986 Oct;25(8):542. No abstract available. PMID: 3533806 </br>8:Contact allergy to amcinonide. Kubo Y, Nonaka S, Yoshida H.Contact Dermatitis. 1986 Aug;15(2):109-11. No abstract available. PMID: 2946521 </br>9:Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis. Huntley AC, Isseroff R.Cutis. 1985 May;35(5):489-92. PMID: 3891239 </br>10:Allergic contact dermatitis from amcinonide. Hayakawa R, Matsunaga K, Ukei C, Hosokawa K.Contact Dermatitis. 1985 Apr;12(4):213-4. PMID: 3160532 |
