AMD-070 hydrochloride

• CAT Number: I005295
• CAS Number: 880549-30-4
• Molecular Formula: C21H30Cl3N5
• Molecular Weight: 458.86
• Purity: ≥95%
• Synonyms: N/’-(1H-benzimidazol-2-ylmethyl)-N/’-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine;hydrochloride
• Target: CXCR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 13 nM
• IUPAC Name: N'-(1H-benzimidazol-2-ylmethyl)-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine;hydrochloride
• InChI: InChI=1S/C21H27N5.ClH/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-11-5-7-16-8-6-13-23-21(16)19;/h1-2,6,8-10,13,19H,3-5,7,11-12,14-15,22H2,(H,24,25);1H/t19-;/m0./s1
• InChIKey: DBNMEMJSDAAGNZ-FYZYNONXSA-N
• SMILES: C1C[C@@H](C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl

AMD-070 HCl(CAT: I005295) is a potent and selective CXCR4 antagonist with an IC₅₀ of 13 nM in a CXCR4 ¹²⁵I-SDF-1 binding assay. By blocking the CXCR4 chemokine receptor, AMD-070 effectively inhibits the interaction between CXCR4 and its natural ligand stromal cell-derived factor-1 (SDF-1/CXCL12). This disruption prevents the entry and replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and peripheral blood mononuclear cells (PBMCs). AMD-070 is widely studied in HIV research and oncology for its role in blocking viral entry and impeding cancer metastasis, particularly in CXCR4-driven tumors.