For research use only. Not for therapeutic Use.
AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer[1].
| Catalog Number | I021941 |
| CAS Number | 478043-30-0 |
| Synonyms | 2-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(3-chlorophenyl)acetonitrile |
| Molecular Formula | C18H8ClF6N3 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H8ClF6N3/c19-10-3-1-2-9(6-10)12(8-26)14-5-4-11-13(17(20,21)22)7-15(18(23,24)25)28-16(11)27-14/h1-7,12H |
| InChIKey | QPWWAOMXYPIDOY-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)C(C#N)C2=NC3=C(C=C2)C(=CC(=N3)C(F)(F)F)C(F)(F)F |
| Reference | [1]. Li M, et, al. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10(3):e0122083. |
