For research use only. Not for therapeutic Use.
AMDE-1(CAT: I021941) (Autophagy Modulator with Dual Effect-1) is a potent autophagy inducer that functions through the AMPK-mTORC1-ULK1 pathway. It triggers autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation. Simultaneously, AMDE-1 inhibits autophagy-mediated degradation by causing lysosomal dysfunction, leading to reduced lysosomal acidity and proteolytic activity. This dual action makes it a valuable tool for studying autophagy regulation and lysosomal function in various cellular processes, including cancer research.
| Catalog Number | I021941 |
| CAS Number | 478043-30-0 |
| Synonyms | 2-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(3-chlorophenyl)acetonitrile |
| Molecular Formula | C18H8ClF6N3 |
| Purity | ≥95% |
| IUPAC Name | 2-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(3-chlorophenyl)acetonitrile |
| InChI | InChI=1S/C18H8ClF6N3/c19-10-3-1-2-9(6-10)12(8-26)14-5-4-11-13(17(20,21)22)7-15(18(23,24)25)28-16(11)27-14/h1-7,12H |
| InChIKey | QPWWAOMXYPIDOY-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)C(C#N)C2=NC3=C(C=C2)C(=CC(=N3)C(F)(F)F)C(F)(F)F |
