For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.<br>Target: alpha and beta-1 receptors<br>Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25). During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. from starting-point. A significant recovery of blood pressure (epidural anaesthesia: syst 21%, diast 9%; spinal anaesthesia: syst 13%, diast 6.6%) and a decrease in heart rate (6.8% resp. 4,5%) are thought due to peripheral vasoconstriction. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia.</p>
| Catalog Number | I003077 |
| CAS Number | 30578-37-1 |
| Molecular Formula | C12H15N3O5S |
| Purity | ≥95% |
| Target | alpha and beta-1 receptors |
| Solubility | DMSO: ≥ 34 mg/mL |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4) |
| InChIKey | ZEASXVYVFFXULL-UHFFFAOYSA-N |
| SMILES | COC1=CC(N)=CN=[N+]1C2=CC=CC=C2.O=S(OC)([O-])=O |
| Reference | </br>1:Leg ulceration during amezinium methylsulfate therapy for hypotension in a hemodialyzed patient with generalized vascular calcification. Kitano Y, Nomura S, Saiki T, Osawa G.Nephron. 1995;71(1):115. No abstract available. PMID: 8538837 </br>2:[Therapeutic use of amezinium methylsulfate–a new, long acting, sympathomimetic–in paraspinal conduction anesthesia]. Schaps D, Seitz W, Mehler D, Tholen A, Goroll D.Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9. German. PMID: 6517242 |
