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51579-82-9-Amfenac Amfenac

Amfenac

For research use only. Not for therapeutic Use.

  • CAT Number: M013159
  • CAS Number: 51579-82-9
  • Molecular Formula: C15H13NO3
  • Molecular Weight: 255.273
  • Purity: ≥95%
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Catalog Number M013159
CAS Number 51579-82-9
Synonyms

2-Amino-3-benzoylbenzeneacetic acid

Molecular Formula C15H13NO3
Purity ≥95%
Storage Room temperature
IUPAC Name 2-(2-amino-3-benzoylphenyl)acetic acid
InChI InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18)
InChIKey SOYCMDCMZDHQFP-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)C(=O)C2=C(C(=CC=C2)CC(=O)O)N
Reference

1: Hiranuma T, Kato S, Hachisu M. Analgesic action of amfenac Na, a non-steroidal
anti-inflammatory agent. J Pharmacobiodyn. 1988 Sep;11(9):612-9. PubMed PMID:
3265150.

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2: Walters T, Raizman M, Ernest P, Gayton J, Lehmann R. In vivo pharmacokinetics
and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. J
Cataract Refract Surg. 2007 Sep;33(9):1539-45. PubMed PMID: 17720067.

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3: Fernandes BF, Marshall JC, Di Cesare S, Logan P, Maloney S, Burnier MN Jr.
Amfenac increases the radiosensitivity of uveal melanoma cell lines. Eye (Lond).
2008 May;22(5):701-6. Epub 2007 Nov 30. PubMed PMID: 18049486.
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4: Yanni SE, Clark ML, Yang R, Bingaman DP, Penn JS. The effects of nepafenac and
amfenac on retinal angiogenesis. Brain Res Bull. 2010 Feb 15;81(2-3):310-9. doi:
10.1016/j.brainresbull.2009.10.018. Epub 2009 Nov 6. PubMed PMID: 19897019;
PubMed Central PMCID: PMC2815002.
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5: Chastain JE, Sanders ME, Curtis MA, Chemuturi NV, Gadd ME, Kapin MA, Markwardt
KL, Dahlin DC. Distribution of topical ocular nepafenac and its active metabolite
amfenac to the posterior segment of the eye. Exp Eye Res. 2016 Apr;145:58-67.
doi: 10.1016/j.exer.2015.10.009. Epub 2015 Oct 22. PubMed PMID: 26474497.
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6: Jain AK, Hunley CC, Kuebel J, McMahon FG, Ryan JJ. Analgesic efficacy of
amfenac, aspirin and placebo after extraction of impacted teeth. Pharmacotherapy.
1986 Sep-Oct;6(5):236-40. PubMed PMID: 3540874.
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7: Ruiz J, López M, Milà J, Lozoya E, Lozano JJ, Pouplana R. QSAR and
conformational analysis of the antiinflammatory agent amfenac and analogues. J
Comput Aided Mol Des. 1993 Apr;7(2):183-98. PubMed PMID: 8320556.

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