AMG-1

• CAT Number: I021957
• CAS Number: 903591-53-7
• Molecular Formula: C18H9ClF5N3O
• Molecular Weight: 413.73
• Purity: 98%
• Synonyms: AMG1; AMG 1; AMG-1
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-(5-(2-Chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamide
• InChI: InChI=1S/C18H9ClF5N3O/c19-11-5-4-9(18(22,23)24)6-10(11)14-7-26-15(8-25-14)27-17(28)16-12(20)2-1-3-13(16)21/h1-8H,(H,26,27,28)
• InChIKey: LWJKSVUJZBEXCH-UHFFFAOYSA-N
• SMILES: O=C(NC1=NC=C(C2=CC(C(F)(F)F)=CC=C2Cl)N=C1)C3=C(F)C=CC=C3F

AMG-1 is a specific CRAC channel inhibitor. AMG-1 blocks the function of effector T cells, but not regulatory T cells in vitro and it attenuates the progression and severity of EAE in vivo.

Reference

1: Li WP, Feng YP, Zhang JT. [Effect of AMG-1 on free intrasynaptosome calcium level and on the isolated artery contraction induced by norepinephrine]. Yao Xue Xue Bao. 1994;29(10):721-4. Chinese. PubMed PMID: 7871995.
2: Liu L, Feng YP. [Effect of AMG-1 and adenosine on glutamate release from synaptosomes in rats]. Yao Xue Xue Bao. 1993;28(12):881-5. Chinese. PubMed PMID: 8030410.
3: Liu L, Feng YP, Hu D, Li HS, Zhang JT. [Effects of AMG-1 on energy metabolism and neuronal damage of ischemic brain in mice and rats]. Yao Xue Xue Bao. 1991;26(12):881-5. Chinese. PubMed PMID: 1823985.