AMG-176

• CAT Number: I002049
• CAS Number: 1883727-34-1
• Molecular Formula: C33H41ClN2O5S
• Molecular Weight: 613.21
• Purity: ≥95%
• Synonyms: AMG-176; AMG 176; AMG176.;Unknown
• Target: Bcl-2 Family
• Solubility: Soluble in DMSO
• Storage: 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
• IUPAC Name: (3'R,4S,6'R,7'S,8'E,11'S,12'R)-7-chloro-7'-methoxy-11',12'-dimethyl-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one
• InChI: InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4+/t21-,22+,25-,27+,30-,33-/m0/s1
• InChIKey: JQNINBDKGLWYMU-GEAQBIRJSA-N
• SMILES: CC1CC=CC(C2CCC2CN3CC4(CCCC5=C4C=CC(=C5)Cl)COC6=C3C=C(C=C6)C(=O)NS(=O)(=O)C1C)OC

AMG-176（Cat No.:I002049）is a selective and potent inhibitor of MCL-1, a protein crucial for cancer cell survival. By targeting MCL-1, AMG-176 promotes apoptosis in cancer cells, particularly in hematologic malignancies such as multiple myeloma and acute myeloid leukemia. This investigational drug disrupts the interaction between MCL-1 and pro-apoptotic proteins, facilitating cancer cell death and enhancing the efficacy of other anticancer therapies. AMG-176 is a promising candidate in oncology research, offering a novel approach to overcoming resistance in cancer treatment and improving patient outcomes.