For research use only. Not for therapeutic Use.
AMG 333(CAT: I019349) is a compound known as a transient receptor potential melastatin 8 (TRPM8) antagonist. It exhibits potent and high selectivity towards the TRPM8 receptor, which is involved in the perception of cold temperatures and the modulation of pain sensation. By blocking the TRPM8 receptor, AMG 333 inhibits its activation and subsequent downstream signaling, leading to a reduction in cold sensitivity and pain transmission.
| Catalog Number | I019349 |
| CAS Number | 1416799-28-4 |
| Molecular Formula | C₂₀H₁₂F₅N₃O₄ |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Reference | [1]. Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201. |
