For research use only. Not for therapeutic Use.
Amifampridine phosphate (Cat No.: I002177) is a salt form of amifampridine, a potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome (LEMS) and certain congenital myasthenic syndromes. By prolonging presynaptic action potentials, it enhances acetylcholine release at neuromuscular junctions, improving muscle strength. It has shown efficacy in rare neuromuscular disorders and is being explored for other neurological conditions. With good bioavailability and tolerability, amifampridine phosphate is a key treatment option for improving mobility and quality of life in LEMS patients.
| CAS Number | 446254-47-3 (phosphate) |
| Synonyms | 3,6-DAP; BRN-0110232; BRN 0110232; BRN0110232; NSC 521760; SC10; Amifampridine; Firdapse; Amifampridine phosphate; Zenas;3,4-Diaminopyridine phosphate |
| Molecular Formula | C5H10N3O4P |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months). |
| IUPAC Name | phosphoric acid;pyridine-3,4-diamine |
| InChI | InChI=1S/C5H7N3.H3O4P/c6-4-1-2-8-3-5(4)7;1-5(2,3)4/h1-3H,7H2,(H2,6,8);(H3,1,2,3,4) |
| InChIKey | KAICRBBQCRKMPO-UHFFFAOYSA-N |
| SMILES | C1=CN=CC(=C1N)N.OP(=O)(O)O |
| Reference | </br>1:Amifampridine phosphate in congenital myasthenic syndrome. Verma S, Mazell SN, Shah DA.Muscle Nerve. 2016 Oct;54(4):809-10. doi: 10.1002/mus.25230. Epub 2016 Jul 19. No abstract available. PMID: 27348204 </br>2:Amifampridine phosphate (Firdapse(®)) is effective and safe in a phase 3 clinical trial in LEMS. Oh SJ, Shcherbakova N, Kostera-Pruszczyk A, Alsharabati M, Dimachkie M, Blanco JM, Brannagan T, Lavrnić D, Shieh PB, Vial C, Meisel A, Komoly S, Schoser B, Sivakumar K, So Y; LEMS Study Group..Muscle Nerve. 2016 May;53(5):717-25. doi: 10.1002/mus.25070. Epub 2016 Mar 3. PMID: 26852139 </br>3:Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults. Haroldsen PE, Musson DG, Hanson B, Quartel A, O/’Neill CA.Clin Ther. 2015 Jul 1;37(7):1555-63. doi: 10.1016/j.clinthera.2015.05.498. Epub 2015 Jun 20. PMID: 26101174 Free Article |
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