Amifostine Hydrate

• CAT Number: I021997
• CAS Number: 63717-27-1
• Molecular Formula: C5H17N2O4PS
• Molecular Weight: 232.23
• Purity: 98%
• Synonyms: Amifostine Hydrate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(3-aminopropylamino)ethylsulfanylphosphonic acid;hydrate
• InChI: InChI=1S/C5H15N2O3PS.H2O/c6-2-1-3-7-4-5-12-11(8,9)10;/h7H,1-6H2,(H2,8,9,10);1H2
• InChIKey: CWHOHHKTRJUFTR-UHFFFAOYSA-N
• SMILES: C(CN)CNCCSP(=O)(O)O.O

Amifostine hydrate（Cat No.:I021997）is a prodrug of amifostine, an organic thiophosphate compound used primarily as a cytoprotective agent to reduce the side effects of chemotherapy and radiation therapy. It works by being converted into its active form, which then scavenges free radicals and protects normal tissues from damage, particularly in the kidneys, bone marrow, and mucous membranes. Amifostine hydrate is used to prevent or reduce the incidence of xerostomia (dry mouth) in head and neck cancer patients undergoing radiation and to protect against nephrotoxicity from certain chemotherapy drugs. Its use is associated with specific dosing and monitoring protocols to minimize side effects.

Reference

1: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2002 Jul-Aug;24(6):371-91. PubMed PMID: 12224444.