Amikacin sulfate

• CAT Number: M100177
• CAS Number: 149022-22-0
• Molecular Formula: C22H43N5O13.9/5H2O4S
• Molecular Weight: 762.14
• Purity: ≥95%
• IUPAC Name: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid
• InChI: InChI=1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
• InChIKey: HIBICIOPDUTNRR-XTHCGPPUSA-N
• SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N.OS(=O)(=O)O

Amikacin sulfate（Cat No.:M100177）is a semi-synthetic aminoglycoside antibiotic derived from kanamycin, widely used against severe Gram-negative bacterial infections. It binds irreversibly to the 30S ribosomal subunit, disrupting protein synthesis and leading to bacterial cell death. Amikacin is highly effective against multidrug-resistant organisms, including Pseudomonas aeruginosa, Acinetobacter, and Enterobacteriaceae. The sulfate salt form ensures improved solubility and stability for clinical use. In research, it serves as a tool for studying antimicrobial resistance and aminoglycoside pharmacology, making it valuable for both therapeutic application and microbiological investigations.