For research use only. Not for therapeutic Use.
Amiloride HCl is a potassium-sparing diuretic widely used in research for its ability to inhibit epithelial sodium channels (ENaC) in the distal renal tubules, reducing sodium reabsorption and potassium excretion. It is also known as a Na⁺/H⁺ exchanger (NHE) inhibitor, making it valuable in studies of hypertension, fluid balance, and acid-base regulation. Additionally, Amiloride HCl is investigated for its effects on cancer, cystic fibrosis, and cardiovascular diseases, providing insights into ion channel physiology and therapeutic strategies targeting electrolyte transport mechanisms.
| Catalog Number | A000184 |
| CAS Number | 2016-88-8 |
| Synonyms | NA |
| Molecular Formula | C6H8ClN7O • HCl |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | store at -20℃ |
| IUPAC Name | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride |
| InChI | 1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H |
| InChIKey | ACHKKGDWZVCSNH-UHFFFAOYSA-N |
| SMILES | C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl |
