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17440-83-4-Amiloride Hydrochloride Dihydrate Amiloride Hydrochloride Dihydrate

Amiloride Hydrochloride Dihydrate

For research use only. Not for therapeutic Use.

  • CAT Number: A000858
  • CAS Number: 17440-83-4
  • Molecular Formula: C6H13Cl2N7O3
  • Molecular Weight: 302.12
  • Purity: ≥95%
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Amiloride is a potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure. Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the kidneys (this mechanism is the same for triamterene). This promotes the loss of sodium and water from the body, but without depleting potassium.


Catalog Number A000858
CAS Number 17440-83-4
Synonyms

17440-83-4; Modamide; Nirulid; Amiloride HCL; Amilorid hydrochlorid-2-wasser

Molecular Formula C6H13Cl2N7O3
Purity ≥95%
Target Sodium Channel
Solubility >14.1mg/mL in DMSO
Storage -20°C
InChI InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
InChIKey LTKVFMLMEYCWMK-UHFFFAOYSA-N
SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl
Reference

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administration of amiloride hydrochloride
(N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate) on
electrolyte balance in the dog. J Pharmacol Exp Ther. 1971 Nov;179(2):438-46.
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activity of N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
dihydrate (amiloride hydrochloride). J Pharmacol Exp Ther. 1967
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in Response to Normobaric Hypoxia in Healthy Individuals. High Alt Med Biol. 2017
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Neuropharmacology. 2017 Oct;125:429-440. doi: 10.1016/j.neuropharm.2017.08.004.
Epub 2017 Aug 9. PubMed PMID: 28802647.

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against HIV-1 TAR. Medchemcomm. 2017 May 1;8(5):1022-1036. doi:
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Is Effective in the Management of Abiraterone-Induced Mineralocorticoid Excess
Syndrome without Interfering with Its Antineoplastic Activity. Pharmacology. 2017
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PMID: 28797006.

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