Aminacrine hydrochloride monohydrate

• CAT Number: I022001
• CAS Number: 52417-22-8
• Molecular Formula: C13H13ClN2O
• Molecular Weight: 248.71
• Purity: 98%
• Synonyms: Aminacrine hydrochloride monohydrate, Aminacrine HCl monohydrate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 9-Acridinamine, monohydrochloride, monohydrate
• InChI: 1S/C13H10N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1-8H,(H2,14,15);1H
• InChIKey: FTGPOQQGJVJDCT-UHFFFAOYSA-N
• SMILES: c12c(c(c3ccccc3n1)[NH2+])cccc2.[ClH-]

Aminacrine hydrochloride monohydrate（Cat No.:I022001)is called Aminacrine HCl monohydrate; Acridin-9-amine hydrochloride hydrate. It is commonly used as an antiseptic, dye preparation, and organic synthesis.

Reference

1: Cerón-Carrasco JP, Ruiz J, Vicente C, de Haro C, Bautista D, Zúñiga J, Requena A. DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III), and Ir(III) Antitumoral Complexes and Their Interaction with DNA. J Chem Theory Comput. 2017 Aug 8;13(8):3898-3910. doi: 10.1021/acs.jctc.7b00139. Epub 2017 Jul 6. PubMed PMID: 28641006.
2: Ishigami-Yuasa M, Watanabe Y, Mori T, Masuno H, Fujii S, Kikuchi E, Uchida S, Kagechika H. Development of WNK signaling inhibitors as a new class of antihypertensive drugs. Bioorg Med Chem. 2017 Jul 15;25(14):3845-3852. doi: 10.1016/j.bmc.2017.05.034. Epub 2017 May 19. PubMed PMID: 28566208.
3: Xiao S, Wang T, Ma X, Qin Y, Li X, Zhao Z, Liu X, Wang X, Xie H, Jiang Q, Sun L, Luo B, Shang L, Chen W, Bai Y, Tang M, He M, Wu L, Ma Q, Hou D, He J. Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer’s disease: a Phase II multicenter randomised controlled trial. Age Ageing. 2017 Sep 1;46(5):767-773. doi: 10.1093/ageing/afx045. PubMed PMID: 28419192.
4: Zhou D, Guo S, Zhang M, Liu Y, Chen T, Li Z. Mass spectrometry imaging of small molecules in biological tissues using graphene oxide as a matrix. Anal Chim Acta. 2017 Apr 15;962:52-59. doi: 10.1016/j.aca.2017.01.043. Epub 2017 Jan 31. PubMed PMID: 28231880.
5: Campbell AP, Wakelin LP, Denny WA, Finch AM. Homobivalent Conjugation Increases the Allosteric Effect of 9-aminoacridine at the α1-Adrenergic Receptors. Mol Pharmacol. 2017 Feb;91(2):135-144. doi: 10.1124/mol.116.105874. Epub 2016 Nov 30. PubMed PMID: 27903755.
6: Kava HW, Murray V. CpG methylation increases the DNA binding of 9-aminoacridine carboxamide Pt analogues. Bioorg Med Chem. 2016 Oct 1;24(19):4701-4710. doi: 10.1016/j.bmc.2016.08.011. Epub 2016 Aug 8. PubMed PMID: 27567075.