Amineptine hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I022006
  • CAS Number: 30272-08-3
  • Molecular Formula: C22H28ClNO2
  • Molecular Weight: 373.92
  • Purity: 98%
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Amineptine hydrochloride is an atypical tricyclic antidepressant (TCA) primarily used in the treatment of neuroses with psychoasthenic, anxio-phobic and depressive manifestations.


Catalog Number I022006
CAS Number 30272-08-3
Synonyms

Amineptine hydrochloride; Amineptine HCl; Maneon; Survector

Molecular Formula C22H28ClNO2
Purity 98%
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name Heptanoic acid, 7-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)-, hydrochloride
InChI InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H
InChIKey VDPUXONTAVMIKZ-UHFFFAOYSA-N
SMILES Cl.OC(=O)CCCCCCNC1c2ccccc2CCc3ccccc13
Reference

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2: Guedes AC, Bentes AA, Machado-Pinto J, Carvalho Mde L. [Acne induced by amineptine]. An Bras Dermatol. 2009 Jan-Feb;84(1):71-4. Portuguese. PubMed PMID: 19377762.
3: Quaglio G, Schifano F, Lugoboni F. Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse. Addiction. 2008 Sep;103(9):1572-4. doi: 10.1111/j.1360-0443.2008.02266.x. Epub 2008 Jul 10. PubMed PMID: 18636997.
4: Mohamed GG, El-Dien FA, Mohamed NA. Utility of 7,7,8,8-tetracyanoquinodimethane charge transfer reagent for the spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides. Spectrochim Acta A Mol Biomol Spectrosc. 2007 Dec 31;68(5):1244-9. Epub 2007 Jan 31. PubMed PMID: 17376736.
5: Mohamed GG, Nour El-Dien FA, Khalil SM, Mohamed NA. Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation with molybdenum and thiocyanate. Spectrochim Acta A Mol Biomol Spectrosc. 2006 Dec;65(5):1221-6. Epub 2006 Jul 10. PubMed PMID: 16829178.
6: Nour El-Dien FA, Mohamed GG, Mohamed NA. Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents. Spectrochim Acta A Mol Biomol Spectrosc. 2006 Sep;65(1):20-6. Epub 2006 Mar 9. PubMed PMID: 16527524.
7: Taïeb O, Larroche C, Dutray B, Baubet T, Moro MR. Fluoxetine dependence in a former amineptine abuser. Am J Addict. 2004 Oct-Dec;13(5):498-500. PubMed PMID: 15764428.
8: De Gálvez Aranda MV, Sánchez PS, Alonso Corral MJ, Bosch García RJ, Gallardo MA, Herrera Ceballos E. Acneiform eruption caused by amineptine. A case report and review of the literature. J Eur Acad Dermatol Venereol. 2001 Jul;15(4):337-9. Review. PubMed PMID: 11730047.
9: Welcome withdrawal of amineptine in France. Prescrire Int. 1999 Apr;8(40):51. PubMed PMID: 10848062.
10: Grimalt R, Mascaró-Galy JM, Ferrando J, Lecha M. Guess what? Macronodular iatrogenic acne due to amineptine. Eur J Dermatol. 1999 Sep;9(6):491-2. PubMed PMID: 10610233.
11: Montejo AL, Llorca G, Izquierdo JA, Carrasco JL, Daniel E, Pérez-Sola V, Vicens E, Bousoño M, Sánchez-Iglesias S, Franco M, Cabezudo A, Rubio V, Ortega MA, Puigdellivol M, Domenech JR, Allué B, Sáez C, Mezquita B, Gálvez I, Pacheco L, de Miguel E. [Sexual dysfunction with antidepressive agents. Effect of the change to amineptine in patients with sexual dysfunction secondary to SSRI]. Actas Esp Psiquiatr. 1999 Jan-Feb;27(1):23-34. Review. Spanish. PubMed PMID: 10380144.
12: Vaugeois JM, Corera AT, Deslandes A, Costentin J. Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacol Biochem Behav. 1999 Jun;63(2):285-90. PubMed PMID: 10371658.
13: Srisurapanont M, Jarusuraisin N, Jittiwutikan J. Amphetamine withdrawal: II. A placebo-controlled, randomised, double-blind study of amineptine treatment. Aust N Z J Psychiatry. 1999 Feb;33(1):94-8. PubMed PMID: 10197891.
14: Boyer P, Lecrubier Y, Stalla-Bourdillon A, Fleurot O. Amisulpride versus amineptine and placebo for the treatment of dysthymia. Neuropsychobiology. 1999;39(1):25-32. PubMed PMID: 9892856.
15: Lapaz AG, Pozo P, Romero H, Barcia D. [A case of Parkinson syndrome secondary to combined amineptine and bromazepam abuse]. Encephale. 1998 Sep-Oct;24(5):486-8. French. PubMed PMID: 9850824.
16: Bettoli V, Trimurti S, Lombardi AR, Virgili A. Acne due to amineptine abuse. J Eur Acad Dermatol Venereol. 1998 May;10(3):281-3. PubMed PMID: 9643342.
17: Perera I, Lim L. Amineptine and midazolam dependence. Singapore Med J. 1998 Mar;39(3):129-31. Review. PubMed PMID: 9632974.
18: Lonardo A, Grisendi A, Mazzone E. One more case of hepatic injury due to amineptine. Ital J Gastroenterol Hepatol. 1997 Dec;29(6):580-1. PubMed PMID: 9513840.
19: Jittiwutikan J, Srisurapanont M, Jarusuraisin N. Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study. J Med Assoc Thai. 1997 Sep;80(9):587-92. PubMed PMID: 9347672.
20: Ferreri M, Colonna L, Leger JM. Efficacy of amineptine in the prevention of relapse in unipolar depression. Int Clin Psychopharmacol. 1997 Jul;12 Suppl 3:S39-45. PubMed PMID: 9347392.

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