For research use only. Not for therapeutic Use.
Amino-PEG1-amine（Cat No.:I014080） is a polyethylene glycol (PEG) derivative that features two amino groups. These amino groups possess reactivity towards various functional groups such as carboxylic acids, activated NHS esters, and carbonyls (ketones, aldehydes). The versatility of amino-PEG1-amine makes it valuable in the development of antibody-drug conjugates and drug delivery systems. It can serve as a linker for attaching therapeutic agents to antibodies, enabling targeted drug delivery and enhancing the efficacy of treatments. Amino-PEG1-amine expands the possibilities for designing innovative drug delivery methods and improving the therapeutic outcomes of pharmaceutical compounds.
| Catalog Number | I014080 |
| CAS Number | 2752-17-2 |
| Synonyms | Amino-PEG1-amine;2,2′-oxybis(ethan-1-amine) |
| Molecular Formula | C4H12N2O |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C(protect from light) |
| IUPAC Name | 2-(2-aminoethoxy)ethanamine |
| InChI | InChI=1S/C4H12N2O/c5-1-3-7-4-2-6/h1-6H2 |
| InChIKey | GXVUZYLYWKWJIM-UHFFFAOYSA-N |
| SMILES | C(COCCN)N |
| Reference | </br>1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. PubMed PMID: 25492012.</br>2: Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chem Commun (Camb). 2011 Jan 21;47(3):988-90. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. PubMed PMID: 21113535.</br>3: Kitagawa F, Kubota K, Sueyoshi K, Otsuka K. One-step preparation of amino-PEG modified poly(methyl methacrylate) microchips for electrophoretic separation of biomolecules. J Pharm Biomed Anal. 2010 Dec 15;53(5):1272-7. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20678876.</br>4: Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG. Chem Commun (Camb). 2008 Nov 14;(42):5369-71. doi: 10.1039/b811818c. Epub 2008 Sep 16. PubMed PMID: 18985213.</br></br> |
