For research use only. Not for therapeutic Use.
Amino-PEG2-(CH2)3COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014089 |
| CAS Number | 1263046-77-0 |
| Synonyms | 4-[2-(2-aminoethoxy)ethoxy]butanoic acid |
| Molecular Formula | C8H17NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H17NO4/c9-3-5-13-7-6-12-4-1-2-8(10)11/h1-7,9H2,(H,10,11) |
| InChIKey | CDXINNRZABLVDW-UHFFFAOYSA-N |
| SMILES | C(CC(=O)O)COCCOCCN |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
