For research use only, not for therapeutic use.
Amino-PEG2-t-Boc-hydrazide(CAT: I014090)is a polyethylene glycol (PEG) derivative that contains an amino group and a tert-butyloxycarbonyl (Boc)-protected hydrazide. The amino group is reactive towards various functional groups, such as carboxylic acids, activated NHS esters, and carbonyls (ketones, aldehydes), enabling the conjugation of the molecule with other compounds. The Boc group serves as a protective group for the hydrazide, which can be selectively deprotected under mild acidic conditions to reveal a reactive hydrazide moiety. This reactive hydrazide can then be coupled with carbonyl groups, facilitating the development of antibody-drug conjugates and other bioconjugates.
| Catalog Number | I014090 |
| CAS Number | 2100306-60-1 |
| Synonyms | Amino-PEG2-t-Boc-hydrazide;tert-butyl 2-(3-(2-(2-aminoethoxy)ethoxy)propanoyl)hydrazine-1-carboxylate |
| Molecular Formula | C12H25N3O5 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C12H25N3O5/c1-12(2,3)20-11(17)15-14-10(16)4-6-18-8-9-19-7-5-13/h4-9,13H2,1-3H3,(H,14,16)(H,15,17) |
| InChIKey | UDVYFYDWDLXHPA-UHFFFAOYSA-N |
| SMILES | NCCOCCOCCC(NNC(OC(C)(C)C)=O)=O |
| Reference | </br>1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. PubMed PMID: 25492012.</br>2: Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chem Commun (Camb). 2011 Jan 21;47(3):988-90. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. PubMed PMID: 21113535.</br>3: Kitagawa F, Kubota K, Sueyoshi K, Otsuka K. One-step preparation of amino-PEG modified poly(methyl methacrylate) microchips for electrophoretic separation of biomolecules. J Pharm Biomed Anal. 2010 Dec 15;53(5):1272-7. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20678876.</br>4: Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG. Chem Commun (Camb). 2008 Nov 14;(42):5369-71. doi: 10.1039/b811818c. Epub 2008 Sep 16. PubMed PMID: 18985213.</br></br> |
