Amino-PEG2-t-butyl ester

• CAT Number: I014091
• CAS Number: 756525-95-8
• Molecular Formula: C11H23NO4
• Molecular Weight: 233.31
• Purity: ≥95%
• Synonyms: Amino-PEG2-t-butyl ester;tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
• Target: Antibody-drug Conjugate/ADC Related
• Solubility: Soluble in DMSO
• Storage: 2–8 °C
• IUPAC Name: tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
• InChI: InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3
• InChIKey: XIVHGTLMLORWEP-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCN

Amino-PEG2-t-butyl ester（Cat No.:I014091） is a PEG derivative that incorporates an amino group and a t-butyl-protected carboxyl group. The amino group can react with various functional groups, such as carboxylic acids, activated NHS esters, and carbonyls (ketone, aldehyde). The t-butyl-protected carboxyl group can be selectively deprotected under acidic conditions. PEG linkers, including Amino-PEG2-t-butyl ester, have potential applications in the development of antibody-drug conjugates, where they serve as spacers between the antibody and the drug, enabling controlled release and improved therapeutic outcomes.

Reference

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