Amino-PEG3-CH2CO2-t-butyl ester

• CAT Number: I014097
• CAS Number: 189808-70-6
• Molecular Formula: C12H25NO5
• Molecular Weight: 263.33
• Purity: ≥95%
• Synonyms: Amino-PEG3-CH2CO2-t-butyl ester;tert-butyl 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)acetate
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• InChI: InChI=1S/C12H25NO5/c1-12(2,3)18-11(14)10-17-9-8-16-7-6-15-5-4-13/h4-10,13H2,1-3H3
• InChIKey: OTTHWLFOQWLZKB-UHFFFAOYSA-N
• SMILES: NCCOCCOCCOCC(OC(C)(C)C)=O

Amino-PEG3-CH2CO2-t-butyl ester (CAT: I014097) is a versatile PEG derivative featuring an amino group coupled with a t-butyl protected carboxyl moiety. This compound acts as a building block for bioconjugation strategies, allowing for precise modification and functionalization of biomolecules. Its mode of action involves facile deprotection of the t-butyl ester, revealing a free carboxyl group that can participate in diverse chemical reactions. This pharmacologic action grants researchers the flexibility to create tailored conjugates for applications ranging from drug delivery and targeted therapy to the development of innovative biomaterials and diagnostics.

Reference

1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. PubMed PMID: 25492012.2: Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chem Commun (Camb). 2011 Jan 21;47(3):988-90. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. PubMed PMID: 21113535.3: Kitagawa F, Kubota K, Sueyoshi K, Otsuka K. One-step preparation of amino-PEG modified poly(methyl methacrylate) microchips for electrophoretic separation of biomolecules. J Pharm Biomed Anal. 2010 Dec 15;53(5):1272-7. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20678876.4: Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG. Chem Commun (Camb). 2008 Nov 14;(42):5369-71. doi: 10.1039/b811818c. Epub 2008 Sep 16. PubMed PMID: 18985213.