Amino-PEG3-CH2COOH

• CAT Number: I014096
• CAS Number: 134978-99-7
• Molecular Formula: C8H17NO5
• Molecular Weight: 207.22
• Purity: ≥95%
• Synonyms: 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C8H17NO5/c9-1-2-12-3-4-13-5-6-14-7-8(10)11/h1-7,9H2,(H,10,11)
• InChIKey: DGRJZSGHEKZYHP-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCC(=O)O)N

Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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