Amino-PEG3-t-butyl ester

• CAT Number: I014099
• CAS Number: 252881-74-6
• Molecular Formula: C13H27NO5
• Molecular Weight: 277.36
• Purity: ≥95%
• Synonyms: Amino-PEG3-t-butyl ester;tert-butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• Storage: -20°C
• IUPAC Name: tert-butyl 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3
• InChIKey: CWFSAZJIJBTKRC-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCN

Amino-PEG3-t-butyl ester（Cat No.:I014099） is a polyethylene glycol (PEG) derivative that features an amino group along with a t-butyl protected carboxyl group. The amino group exhibits reactivity towards carboxylic acids, activated NHS esters, and carbonyl compounds like ketones and aldehydes. The t-butyl protected carboxyl group can be selectively removed under acidic conditions. PEG linkers, such as Amino-PEG3-t-butyl ester, have potential applications in the development of antibody-drug conjugates, enabling the attachment of drugs to antibodies for targeted delivery in various therapeutic applications.

Reference

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