Amino-PEG4-acid

• CAT Number: I014100
• CAS Number: 663921-15-1
• Molecular Formula: C11H23NO6
• Molecular Weight: 265.31
• Purity: ≥95%
• Synonyms: Amino-PEG4-acid;1-amino-3,6,9,12-tetraoxapentadecan-15-oic acid
• Target: PROTAC
• Solubility: Soluble in DMSO
• Storage: 2-8°C
• IUPAC Name: 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
• InChIKey: DKUZHSDZSMQOGQ-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCN)C(=O)O

NH2-PEG4-CH2CH2COOH（Cat No.:I014100） is a versatile cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) and PEG-based PROTACs. A 4-unit polyethylene glycol (PEG) backbone provides stability and solubility to the conjugates. The linker contains an amine group (NH2) that allows for attachment to the drug or ligand of interest. The linker can be cleaved upon internalization into target cells, releasing the therapeutic payload or PROTAC for selective targeting and drug delivery. NH2-PEG4-CH2CH2COOH offers a flexible and effective platform for the development of targeted therapies and drug delivery systems.

Reference

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