Amino-PEG4-amine(CAT: I014101) is a polyethylene glycol (PEG) derivative possessing two amino groups. These amino groups demonstrate reactivity with various functional groups including carboxylic acids, activated NHS esters, and carbonyls such as ketones and aldehydes. This versatile compound serves as a linker with potential applications in antibody-drug conjugate development and drug delivery strategies. By offering controlled and specific points of attachment, PEG linkers like Amino-PEG4-amine contribute to the design of advanced pharmaceutical agents, facilitating precise targeting and efficient delivery of therapeutic compounds.
| Catalog Number | I014101 |
| CAS Number | 68960-97-4 |
| Synonyms | Amino-PEG4-amine;3,6,9,12-tetraoxatetradecane-1,14-diamine |
| Molecular Formula | C10H24N2O4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C10H24N2O4/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h1-12H2 |
| InChIKey | IFZOPNLVYZYSMQ-UHFFFAOYSA-N |
| SMILES | NCCOCCOCCOCCOCCN |
| Reference | </br>1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. PubMed PMID: 25492012.</br>2: Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chem Commun (Camb). 2011 Jan 21;47(3):988-90. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. PubMed PMID: 21113535.</br>3: Kitagawa F, Kubota K, Sueyoshi K, Otsuka K. One-step preparation of amino-PEG modified poly(methyl methacrylate) microchips for electrophoretic separation of biomolecules. J Pharm Biomed Anal. 2010 Dec 15;53(5):1272-7. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20678876.</br>4: Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG. Chem Commun (Camb). 2008 Nov 14;(42):5369-71. doi: 10.1039/b811818c. Epub 2008 Sep 16. PubMed PMID: 18985213.</br></br> |
