Amino-PEG5-acid

• CAT Number: I014106
• CAS Number: 1191078-74-6
• Molecular Formula: C13H27NO7
• Molecular Weight: 309.36
• Purity: ≥95%
• Synonyms: Amino-PEG5-acid;1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
• Target: PROTAC
• Solubility: Soluble in DMSO
• IUPAC Name: 3-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C13H27NO7/c14-2-4-18-6-8-20-10-12-21-11-9-19-7-5-17-3-1-13(15)16/h1-12,14H2,(H,15,16)
• InChIKey: ZTYIBTVLGAIXDY-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCN)C(=O)O

Amino-PEG5-C2-acid is a linker molecule belonging to the polyethylene glycol (PEG) class and used in the synthesis of PROTAC molecules. It serves as a non-cleavable linker in the construction of antibody-drug conjugates (ADCs). By incorporating Amino-PEG5-C2-acid, a series of PROTAC molecules can be synthesized, enabling targeted protein degradation. This linker provides stability and flexibility to the ADC construct, facilitating the selective delivery of drugs to the desired target cells. Amino-PEG5-C2-acid plays a crucial role in the development of novel therapeutic strategies and the advancement of targeted cancer treatments.

Reference

1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. PubMed PMID: 25492012.2: Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chem Commun (Camb). 2011 Jan 21;47(3):988-90. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. PubMed PMID: 21113535.3: Kitagawa F, Kubota K, Sueyoshi K, Otsuka K. One-step preparation of amino-PEG modified poly(methyl methacrylate) microchips for electrophoretic separation of biomolecules. J Pharm Biomed Anal. 2010 Dec 15;53(5):1272-7. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20678876.4: Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG. Chem Commun (Camb). 2008 Nov 14;(42):5369-71. doi: 10.1039/b811818c. Epub 2008 Sep 16. PubMed PMID: 18985213.