For research use only. Not for therapeutic Use.
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014108 |
| CAS Number | 141282-35-1 |
| Synonyms | 2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid |
| Molecular Formula | C12H25NO7 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H25NO7/c13-1-2-16-3-4-17-5-6-18-7-8-19-9-10-20-11-12(14)15/h1-11,13H2,(H,14,15) |
| InChIKey | ZQGSSZVORHCAFC-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCOCCOCC(=O)O)N |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
