For research use only. Not for therapeutic Use.
Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
| Catalog Number | I042962 |
| CAS Number | 1416771-72-6 |
| Synonyms | 3-[2-amino-3-(2-carboxyethoxy)-2-(2-carboxyethoxymethyl)propoxy]propanoic acid;hydrochloride |
| Molecular Formula | C13H24ClNO9 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H23NO9.ClH/c14-13(7-21-4-1-10(15)16,8-22-5-2-11(17)18)9-23-6-3-12(19)20;/h1-9,14H2,(H,15,16)(H,17,18)(H,19,20);1H |
| InChIKey | ACGZZBXQNDTJIA-UHFFFAOYSA-N |
| SMILES | C(COCC(COCCC(=O)O)(COCCC(=O)O)N)C(=O)O.Cl |
| Reference | [1]. Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2. [2]. David Margulies, et al. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof. WO2015166491A2. |
