Amino-Tri-(carboxyethoxymethyl)-methane

• CAT Number: I014120
• CAS Number: 174362-95-9
• Molecular Formula: C13H23NO9
• Molecular Weight: 337.33
• Purity: ≥95%
• Synonyms: Amino-Tri-(carboxyethoxymethyl)-methane;3,3′-((2-amino-2-((2-carboxyethoxy)methyl)propane-1,3-diyl)bis(oxy))dipropionic acid
• Target: PROTAC
• Solubility: Soluble in DMSO
• IUPAC Name: 3-[2-amino-3-(2-carboxyethoxy)-2-(2-carboxyethoxymethyl)propoxy]propanoic acid
• InChI: InChI=1S/C13H23NO9/c14-13(7-21-4-1-10(15)16,8-22-5-2-11(17)18)9-23-6-3-12(19)20/h1-9,14H2,(H,15,16)(H,17,18)(H,19,20)
• InChIKey: PZOSHMSOMAHCEX-UHFFFAOYSA-N
• SMILES: NC(COCCC(O)=O)(COCCC(O)=O)COCCC(O)=O

Amino-Tri-(carboxyethoxymethyl)-methane (Cat No.: I014120), also known as ATCEM, is a polycarboxylate compound with strong chelating properties. It is widely used in industrial applications, including water treatment, detergents, and as a stabilizer in chemical formulations. Its ability to bind metal ions makes it useful in preventing scale formation and improving solubility in various processes. ATCEM also plays a role in biomedical research as a chelating agent for metal-based drug delivery and diagnostic imaging. Its stability and low toxicity make it a valuable additive in multiple industries.

Reference

1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. PubMed PMID: 25492012.2: Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chem Commun (Camb). 2011 Jan 21;47(3):988-90. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. PubMed PMID: 21113535.3: Kitagawa F, Kubota K, Sueyoshi K, Otsuka K. One-step preparation of amino-PEG modified poly(methyl methacrylate) microchips for electrophoretic separation of biomolecules. J Pharm Biomed Anal. 2010 Dec 15;53(5):1272-7. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20678876.4: Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG. Chem Commun (Camb). 2008 Nov 14;(42):5369-71. doi: 10.1039/b811818c. Epub 2008 Sep 16. PubMed PMID: 18985213.