Aminoacyl tRNA synthetase-IN-1

• CAT Number: I013003
• CAS Number: 219931-45-0
• Molecular Formula: C₁₆H₂₅N₇O₇S
• Molecular Weight: 459.48
• Purity: ≥95%
• Target: Bacterial; Aminoacyl-tRNA Synthetase
• Solubility: DMSO
• IUPAC Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S,3S)-2-amino-3-methylpentanoyl]sulfamate
• InChI: InChI=1S/C16H25N7O7S/c1-3-7(2)9(17)15(26)22-31(27,28)29-4-8-11(24)12(25)16(30-8)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,16,24-25H,3-4,17H2,1-2H3,(H,22,26)(H2,18,19,20)/t7-,8+,9-,11+,12+,16+/m0/s1
• InChIKey: ADKZHDGLJXVNIT-VBJYJYTRSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)NS(=O)(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)N

Aminoacyl tRNA Synthetase-IN-1（Cat No.:I013003）is a selective inhibitor targeting aminoacyl-tRNA synthetases, enzymes essential for protein synthesis by linking amino acids to their corresponding tRNAs. By blocking this process, it disrupts protein translation, making it valuable in cancer research and in studying diseases where protein synthesis modulation is relevant. Aminoacyl tRNA Synthetase-IN-1 has shown promise in preclinical models for its potential to slow cell proliferation in certain cancers, providing insights into therapeutic applications. Its specificity allows researchers to explore protein synthesis pathways and potential new treatments in targeted disease areas.

Reference

[1]. Vondenhoff GH, et al. Microcin C and albomycin analogues with aryl-tetrazole substituents as nucleobase isosters areselective inhibitors of bacterial aminoacyl tRNA synthetases but lack efficient uptake. Chembiochem. 2012 Sep 3;13(13):1959-69.