For research use only. Not for therapeutic Use.
Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
| Catalog Number | I014048 |
| CAS Number | 1043426-13-6 |
| Synonyms | O-[2-[2-(2-azidoethoxy)ethoxy]ethyl]hydroxylamine |
| Molecular Formula | C6H14N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H14N4O3/c7-10-9-1-2-11-3-4-12-5-6-13-8/h1-6,8H2 |
| InChIKey | GCURLNTZWQFVMK-UHFFFAOYSA-N |
| SMILES | C(COCCOCCON)N=[N+]=[N-] |
| Reference | [1]. H. Tetsuo Uyeda, et al. Synthesis of surface ligands to prepare hydrophilic and biologically compatible quantum dots. doi: 10.1117/12.590494. [2]. Song, Ho Young, et al. Pyrrolobenzodiazepine dimer precursor and ligand-linker conjugate compound thereof. |
