For research use only. Not for therapeutic Use.
Aminooxy-PEG3-C2-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I014058 |
| CAS Number | 1200365-63-4 |
| Synonyms | O-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethyl]hydroxylamine |
| Molecular Formula | C8H19NO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C8H19NO4S/c9-13-6-5-11-2-1-10-3-4-12-7-8-14/h14H,1-9H2 |
| InChIKey | PPTKPSRJLDTYOY-UHFFFAOYSA-N |
| SMILES | C(COCCON)OCCOCCS |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
