For research use only. Not for therapeutic Use.
Aminooxy-PEG4-propargyl (Cat No.: I014063) is a heterobifunctional polyethylene glycol (PEG) linker featuring an aminooxy group and a propargyl (alkyne) group, designed for advanced bioconjugation applications. The aminooxy group reacts selectively with carbonyl-containing compounds (e.g., aldehydes and ketones) to form stable oxime bonds, while the propargyl group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) “click” reactions. The PEG4 spacer enhances water solubility and reduces steric hindrance, making this linker ideal for constructing multifunctional biomolecules, labeling, and surface modification in chemical biology, diagnostics, and drug delivery systems.
| CAS Number | 1835759-78-8 |
| Synonyms | Aminooxy-PEG4-propargyl;O-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hydroxylamine |
| Molecular Formula | C11H21NO5 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C11H21NO5/c1-2-3-13-4-5-14-6-7-15-8-9-16-10-11-17-12/h1H,3-12H2 |
| InChIKey | BGPKKFCCGOYRRN-UHFFFAOYSA-N |
| SMILES | NOCCOCCOCCOCCOCC#C |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. </br>2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.</br>3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.</br>4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. </br>5: Kanazaki K, Sano K, Makino A, Yamauchi F, Takahashi A, Homma T, Ono M, Saji H. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. doi:10.1016/j.jconrel.2016.02.017. Epub 2016 Feb 8. PubMed PMID: 26869546.</br> </br> |
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