Aminooxy-PEG5-azide

• CAT Number: I014065
• CAS Number: 1919045-02-5
• Molecular Formula: C12H26N4O6
• Molecular Weight: 322.36
• Purity: ≥95%
• Synonyms: O-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]hydroxylamine
• InChI: InChI=1S/C12H26N4O6/c13-16-15-1-2-17-3-4-18-5-6-19-7-8-20-9-10-21-11-12-22-14/h1-12,14H2
• InChIKey: TZMRTDAQRAJMRO-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCON)N=[N+]=[N-]

Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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