For research use only. Not for therapeutic Use.
Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells[1].
Amiprofos methyl (APM) inhibits competitively the binding of [14C]oryzalin to tubulin with a Ki=5 μM. Amiprofos methyl concentrations inhibiting tobacco cell growth were within the threshold range of Amiprofos methyl concentrations that depolymerized cellular microtubules, indicating that growth inhibition is caused by microtubules depolymerization[2].
| Catalog Number | R069825 |
| CAS Number | 36001-88-4 |
| Synonyms | N-[methoxy-(4-methyl-2-nitrophenoxy)phosphinothioyl]propan-2-amine |
| Molecular Formula | C11H17N2O4PS |
| Purity | ≥95% |
| InChI | InChI=1S/C11H17N2O4PS/c1-8(2)12-18(19,16-4)17-11-6-5-9(3)7-10(11)13(14)15/h5-8H,1-4H3,(H,12,19) |
| InChIKey | VHEWQRWLIDWRMR-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)OP(=S)(NC(C)C)OC)[N+](=O)[O-] |
| Reference | [1]. Morejohn LC, et al. Inhibition of Plant Microtubule Polymerization in vitro by the Phosphoric Amide Herbicide Amiprophos-Methyl. Science. 1984;224(4651):874-876. [2]. Murthy JV, et al. Competitive Inhibition of High-Affinity Oryzalin Binding to Plant Tubulin by the Phosphoric Amide Herbicide Amiprophos-Methyl. Plant Physiol. 1994;105(1):309-320. |
