For research use only. Not for therapeutic Use.
Amisulpride（Cat No.:A000204）is an atypical antipsychotic used primarily to treat schizophrenia and, in lower doses, depression. It works by selectively blocking dopamine D2 and D3 receptors, particularly in the limbic system, reducing symptoms such as hallucinations, delusions, and emotional disturbances. Unlike other antipsychotics, Amisulpride exhibits a low affinity for serotonin receptors, which helps reduce side effects like sedation and weight gain. It is well-tolerated and effective in managing both positive and negative symptoms of schizophrenia, offering an improved quality of life for patients with fewer cognitive and motor side effects.
| Catalog Number | A000204 |
| CAS Number | 71675-85-9 |
| Synonyms | 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide |
| Molecular Formula | C17H27N3O4S |
| Purity | 98% |
| Target | DRD2 |
| Target Protein | |
| Appearance | Solid |
| Storage | Dry, dark and at 2 - 8 °C for six months or -20°C for two years. |
| IC50 | Ki: 2.8 nM (D2 receptor), 3.2 nM (D3 receptor) |
| IUPAC Name | 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide |
| InChI | InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) |
| InChIKey | NTJOBXMMWNYJFB-UHFFFAOYSA-N |
| SMILES | CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC |
| Reference | [1]. Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280(1):83-97. [2]. Pawar GR, et al. Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. Acta Pol Pharm. 2009 May-Jun;66(3):327-31. |
