Amitifadine hydrochloride

• CAT Number: I003492
• CAS Number: 410074-74-7
• Molecular Formula: C11H12Cl3N
• Molecular Weight: 264.58
• Purity: ≥95%
• Target: Serotonin Transporter
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 12/23/96 nM, 99/262/213 nM (Ki, for SERT/NET/ DAT)
• IUPAC Name: (1R,5S)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane;hydrochloride
• InChI: InChI=1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H/t8-,11+;/m1./s1
• InChIKey: KAGBHVBIOJBGBD-NINOIYOQSA-N
• SMILES: C1[C@H]2[C@@]1(CNC2)C3=CC(=C(C=C3)Cl)Cl.Cl

Amitifadine hydrochloride（Cat No.:I003492）is a novel experimental compound primarily investigated for its potential use in treating depression and other mood disorders. It acts as a selective serotonin, norepinephrine, and dopamine reuptake inhibitor (SSNDRI), similar to certain antidepressants, but with a unique pharmacological profile. By increasing the levels of these neurotransmitters in the brain, amitifadine may help alleviate symptoms of depression and anxiety. It has also been explored for its potential to treat conditions like fibromyalgia. Ongoing clinical trials are assessing its safety, efficacy, and overall therapeutic potential.

Reference

[1]. Amitifadine
[2]. Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a /triple/ reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.
[3]. Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37.