For research use only. Not for therapeutic Use.
Amitraz（Cat No.:I003188）is a potent acaricide and insecticide widely used in agriculture and veterinary medicine for controlling ectoparasites, particularly ticks and mites, in livestock and pets. It functions by inhibiting monoamine oxidase (MAO), leading to the accumulation of neurotransmitters, which disrupts the nervous system of the target pests. Amitraz is effective against a range of ectoparasites, making it valuable in managing infestations. However, it requires careful handling due to its toxicity to non-target species, including beneficial insects and aquatic organisms. Monitoring and adherence to safety guidelines are essential during its application.
| Catalog Number | I003188 |
| CAS Number | 33089-61-1 |
| Molecular Formula | C19H23N3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20℃ |
| IUPAC Name | N'-(2,4-dimethylphenyl)-N-[(2,4-dimethylphenyl)iminomethyl]-N-methylmethanimidamide |
| InChI | InChI=1S/C19H23N3/c1-14-6-8-18(16(3)10-14)20-12-22(5)13-21-19-9-7-15(2)11-17(19)4/h6-13H,1-5H3 |
| InChIKey | QXAITBQSYVNQDR-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)N=CN(C)C=NC2=C(C=C(C=C2)C)C)C |
| Reference | </br>1:Amitraz changes NE, DA and 5-HT biosynthesis and metabolism mediated by alterations in estradiol content in CNS of male rats. Del Pino J, Moyano P, Ruiz M, Anadón MJ, Díaz MJ, García JM, Labajo-González E, Frejo MT.Chemosphere. 2017 Aug;181:518-529. doi: 10.1016/j.chemosphere.2017.04.113. Epub 2017 Apr 26. PMID: 28463726 </br>2:The current status of resistance to alpha-cypermethrin, ivermectin, and amitraz of the cattle tick (Rhipicephalus microplus) in Ecuador. Rodríguez-Hidalgo R, Pérez-Otáñez X, Garcés-Carrera S, Vanwambeke SO, Madder M, Benítez-Ortiz W.PLoS One. 2017 Apr 7;12(4):e0174652. doi: 10.1371/journal.pone.0174652. eCollection 2017. PMID: 28388639 Free PMC Article</br>3:Simultaneous determination of amitraz, chlordimeform, formetanate and their main metabolites in human urine by high performance liquid chromatography-tandem mass spectrometry. Gao X, Tan Y, Guo H.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:27-33. doi: 10.1016/j.jchromb.2017.03.004. Epub 2017 Mar 11. PMID: 28346886 </br>4:Detection of amitraz and malathion resistance in field populations of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) in Jammu region of India. Dutta S, Godara R, Katoch R, Yadav A, Katoch M, Singh NK.Exp Appl Acarol. 2017 Mar;71(3):291-301. doi: 10.1007/s10493-017-0111-4. Epub 2017 Mar 1. PMID: 28251410 </br>5:The effects of sub-chronic administration of sub-lethal doses of amitraz/xylene on selected reproductive parameters of male Wistar rats. Omoja VU, Anika SM, Asuzu IU.Iran J Vet Res. 2016 Fall;17(4):277-280. PMID: 28224014 Free PMC Article</br>6:Amitraz, an underrecognized poison: A systematic review. Dhooria S, Agarwal R.Indian J Med Res. 2016 Sep;144(3):348-358. doi: 10.4103/0971-5916.198723. Review. PMID: 28139533 Free PMC Article</br>7:Amitraz poisoning: A case report of an unusual pesticide poisoning in Sri Lanka and literature review. Herath HM, Pahalagamage SP, Yogendranathan N, Wijayabandara MD, Kulatunga A.BMC Pharmacol Toxicol. 2017 Jan 23;18(1):6. doi: 10.1186/s40360-016-0114-5. PMID: 28110639 Free PMC Article</br>8:Acute Exposure to Worst-Case Concentrations of Amitraz Does Not Affect Honey Bee Learning, Short-Term Memory, or Hemolymph Octopamine Levels. Rix RR, Christopher Cutler G.J Econ Entomol. 2017 Feb 1;110(1):127-132. doi: 10.1093/jee/tow250. PMID: 28028168 </br>9:First report of amitraz and cypermethrin resistance in Rhipicephalus sanguineus sensu lato infesting dogs in Mexico. Rodriguez-Vivas RI, Ojeda-Chi MM, Trinidad-Martinez I, Bolio-González ME.Med Vet Entomol. 2017 Mar;31(1):72-77. doi: 10.1111/mve.12207. Epub 2016 Nov 11. PMID: 27859488 </br>10:Amitraz poisoning: an unusual cause of respiratory and peripheral circulatory failure. Agrawal I, Ahmad S, Kumar M, Akram M.Trop Doct. 2016 Nov 8. pii: 0049475516677159. [Epub ahead of print] PMID: 27827799 |
