Amitriptyline hydrochloride

• CAT Number: I004032
• CAS Number: 549-18-8
• Molecular Formula: C20H23N • HCl
• Molecular Weight: 313.9
• Purity: ≥95%
• Synonyms: 3-(5,6-dihydrodibenzo[2,1-b:2/’,1/’-f][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
• Target: GPCR/G Protein
• Solubility: DMSO 60 mg/mL; Water 15 mg/mL
• Storage: 3 years -20C powder
• InChIKey: KFYRPLNVJVHZGT-UHFFFAOYSA-N

Amitriptyline hydrochloride(CAT: I004032) is a tricyclic antidepressant (TCA) belonging to the dibenzocycloheptene derivative class. It acts by inhibiting the reuptake of serotonin and norepinephrine, thereby increasing their availability in the brain. Amitriptyline hydrochloride is primarily prescribed for the treatment of major depressive disorder, but it is also used in the management of various other conditions, including neuropathic pain, migraines, and insomnia.

Reference

[1]. Tatsumi, M., et al., Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol, 1997. 340(2-3): p. 249-58.

[2]. http://en.wikipedia.org/wiki/Amitriptyline

[3]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56.