Amlexanox

• CAT Number: I004569
• CAS Number: 68302-57-8
• Molecular Formula: C16H14N2O4
• Molecular Weight: 298.29
• Purity: ≥95%
• Synonyms: AA 673
• Target: IKK
• Solubility: 100 mM in DMSO
• Storage: -20°C
• IC50: 1-2 uM [1]
• IUPAC Name: 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid
• InChI: InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
• InChIKey: SGRYPYWGNKJSDL-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC=C2C(C(C(C=C(C(O)=O)C(N)=N3)=C3O2)=O)=C1

Amlexanox(CAT: I004569) is an anti-inflammatory and antiallergic compound that functions as an inhibitor of IKKε (IκB kinase ε) and TBK1 (TANK-binding kinase 1), key regulators of the NF-κB and IRF3 signaling pathways. By targeting these kinases, Amlexanox reduces pro-inflammatory cytokine production and modulates metabolic pathways. It is widely studied for its potential in treating chronic inflammatory diseases, obesity, and type 2 diabetes, as it has been shown to improve insulin sensitivity and metabolic profiles in preclinical models. Amlexanox is also known for its use in treating aphthous ulcers, offering anti-inflammatory effects in localized mucosal conditions. Its dual therapeutic applications make it a valuable tool in metabolic and immunological research.