Amlodipine-d4

• CAT Number: R055683
• CAS Number: 1185246-14-3
• Molecular Formula: C20H25ClN2O5
• Molecular Weight: 412.903
• Purity: ≥95%
• Synonyms: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine-d4; (R,S)-Amlodipine-d4; Amlopres-d4; Intervask-d4; Pelmec-d4; UK-48340-d4
• Storage: Store at 4°C
• IUPAC Name: 3-O-ethyl 5-O-methyl 2-[(2-amino-1,1,2,2-tetradeuterioethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• InChI: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/i9D2,10D2
• InChIKey: HTIQEAQVCYTUBX-YQUBHJMPSA-N
• SMILES: [2H]C([2H])(C([2H])([2H])OCC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2Cl)C(=O)OCC)N

Amlodipine-d4 is a deuterated form of amlodipine, a widely used calcium channel blocker for the treatment of hypertension and angina. This compound features four deuterium atoms, which enhance its stability and allow for precise tracking in pharmacokinetic studies, drug metabolism research, and isotope-dilution mass spectrometry. Amlodipine-d4 is particularly valuable in investigating the absorption, distribution, metabolism, and excretion (ADME) of amlodipine in biological systems. It serves as a reliable internal standard in analytical chemistry, ensuring accurate and reproducible results in pharmaceutical research, especially in the study and development of cardiovascular therapies.