Amlodipine

• CAT Number: I000483
• CAS Number: 88150-42-9
• Molecular Formula: C20H25ClN2O5
• Molecular Weight: 408.88
• Purity: ≥95%
• Synonyms: Amlodis; Norvasc; Amlocard; Coroval; Amlodipine Besylate; Amlodipine Maleate; Amlodipine Maleate;(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 4°C
• IUPAC Name: 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• InChI: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
• InChIKey: HTIQEAQVCYTUBX-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN

Amlodipine(CAT: I000483) is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle and cardiac muscle. By reducing calcium influx, Amlodipine causes vasodilation, leading to decreased peripheral vascular resistance and blood pressure. It is widely used in the treatment of hypertension, chronic stable angina, and vasospastic angina. Amlodipine’s long half-life allows for once-daily dosing, contributing to its efficacy and patient compliance. In research, it serves as a key tool for studying cardiovascular pharmacology, calcium channel regulation, and therapeutic strategies for managing cardiovascular diseases.