For research use only. Not for therapeutic Use.
Amlodipine (as besylate, mesylate or maleate) is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina.
| Catalog Number | I000483 |
| CAS Number | 88150-42-9 (Amlodipine) |
| Synonyms | Amlodis; Norvasc; Amlocard; Coroval; Amlodipine Besylate; Amlodipine Maleate; Amlodipine Maleate;(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Molecular Formula | C20H25ClN2O5 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at 4°C |
| IUPAC Name | 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| InChI | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 |
| InChIKey | HTIQEAQVCYTUBX-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN |
| Reference | </br>1:Multiway analysis methods applied to the fluorescence excitation-emission dataset for the simultaneous quantification of valsartan and amlodipine in tablets. Dinç E, Ertekin ZC, Büker E.Spectrochim Acta A Mol Biomol Spectrosc. 2017 Apr 30;184:255-261. doi: 10.1016/j.saa.2017.04.081. [Epub ahead of print] PMID: 28514719 </br>2:Effects of valsartan and amlodipine on oxidative stress in type 2 diabetic patients with hypertension: a randomized, multicenter study. Kim HJ, Han SJ, Kim DJ, Jang HC, Lim S, Choi SH, Kim YH, Shin DH, Kim SH, Kim TH, Ahn YB, Ko SH, Kim NH, Seo JA, Kim HY, Lee KW.Korean J Intern Med. 2017 May;32(3):497-504. doi: 10.3904/kjim.2015.404. Epub 2016 Dec 30. PMID: 28490725 Free PMC Article</br>3:Adherence to Treatment, Safety, Tolerance, and Effectiveness of Perindopril/Amlodipine Fixed-Dose Combination in Greek Patients with Hypertension and Stable Coronary Artery Disease: A Pan-Hellenic Prospective Observational Study of Daily Clinical Practice. Liakos CI, Papadopoulos DP, Kotsis VT.Am J Cardiovasc Drugs. 2017 May 2. doi: 10.1007/s40256-017-0232-5. [Epub ahead of print] PMID: 28466368 </br>4:Blood Pressure Variability in Patients with Diabetes Mellitus with Hypertension: Treatment Recommendations and Role of Amlodipine. Sethi BK, Baruah MP, Kumar AS.J Assoc Physicians India. 2017 Mar;65(3):67-71. Review. PMID: 28462546 </br>5:Efficacy of olmesartan amlodipine in Colombian hypertensive patients (soat study). Buendia R, Zambrano M.BMC Res Notes. 2017 Apr 26;10(1):164. doi: 10.1186/s13104-017-2486-z. PMID: 28441972 Free PMC Article</br>6:Amlodipine: The double edged sword. Rabah F, El-Naggari M, Al-Nabhani D.J Paediatr Child Health. 2017 Apr 7. doi: 10.1111/jpc.13517. [Epub ahead of print] PMID: 28387969 </br>7:Development, validation and comparison of near infrared and Raman spectroscopic methods for fast characterization of tablets with amlodipine and valsartan. Casian T, Reznek A, Vonica-Gligor AL, Van Renterghem J, De Beer T, Tomuță I.Talanta. 2017 May 15;167:333-343. doi: 10.1016/j.talanta.2017.01.092. Epub 2017 Feb 7. PMID: 28340729 </br>8:Blood pressure-lowering efficacy and safety of perindopril/indapamide/amlodipine single-pill combination in patients with uncontrolled essential hypertension: a multicenter, randomized, double-blind, controlled trial. Mourad JJ, Amodeo C, de Champvallins M, Brzozowska-Villatte R, Asmar R; study coordinators, investigators..J Hypertens. 2017 May 2. doi: 10.1097/HJH.0000000000001359. [Epub ahead of print] PMID: 28306636 </br>9:[Efficacy and Safety of a Fixed Combination of Perindopril Arginine and Amlodipine in Patients With Hypertension Uncontrolled by Treatment With Angiotensin II Receptor Blockers in Real Clinical Practice. Results of the PREVOSHODSTVO (SUPERIORITY) Program]. Ostroumova OD.Kardiologiia. 2017 Jan;(1):30-36. Russian. PMID: 28290831 </br>10:[Effects of Amlodipine/Lisinopril Fixed-Dose Combination on Severity of Left Ventricular Hypertrophy and Parameters of Myocardial Stiffness in Patients With Hypertension]. Ostroumova OD, Kochetkov AI.Kardiologiia. 2016 Dec;56(11):27-37. Russian. PMID: 28290816 |
