For research use only. Not for therapeutic Use.
AMN082 is an mGluR II and III activator.
| Catalog Number | I002241 |
| CAS Number | 97075-46-2 |
| Synonyms | AMN 082; AMN-082; AMN082;N,N/’-bis[di(phenyl)methyl]ethane-1,2-diamine |
| Molecular Formula | C28H30Cl2N2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | Desiccate at +4C |
| IUPAC Name | N,N/'-dibenzhydrylethane-1,2-diamine;dihydrochloride |
| InChI | InChI=1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H |
| InChIKey | YRQCDCNQANSUPB-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl |
| Reference | </br>1:Off-target potential of AMN082 on sleep EEG and related physiological variables: Evidence from mGluR7 (-/-) mice. Ahnaou A, Raeyemaekers L, Huysmans H, Drinkenburg WH.Behav Brain Res. 2016 Sep 15;311:287-97. doi: 10.1016/j.bbr.2016.05.035. Epub 2016 May 17. PMID: 27211063 </br>2:Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death. Domin H, Jantas D, Śmiałowska M.Neurochem Int. 2015 Sep;88:110-23. doi: 10.1016/j.neuint.2014.12.010. Epub 2015 Jan 6. PMID: 25576184 </br>3:AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. Jenda M, Gawel K, Marszalek M, Komsta L, Kotlinska JH.Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:166-75. doi: 10.1016/j.pnpbp.2014.11.004. Epub 2014 Nov 13. PMID: 25448778 </br>4:Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats. Pałucha-Poniewiera A, Szewczyk B, Pilc A.Neuropharmacology. 2014 Jul;82:59-68. doi: 10.1016/j.neuropharm.2014.03.001. Epub 2014 Mar 12. PMID: 24631968 </br>5:Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082. Konieczny J, Lenda T.Pharmacol Rep. 2013;65(5):1194-203. PMID: 24399715 Free Article</br>6:Positive allosteric modulation of mGlu7 receptors by AMN082 affects sleep and wakefulness in the rat. Cavas M, Scesa G, Navarro JF.Pharmacol Biochem Behav. 2013 Feb;103(4):756-63. doi: 10.1016/j.pbb.2012.12.008. Epub 2012 Dec 21. PMID: 23262401 </br>7:A selective mGlu7 receptor antagonist MMPIP reversed antidepressant-like effects of AMN082 in rats. Pałucha-Poniewiera A, Pilc A.Behav Brain Res. 2013 Feb 1;238:109-12. doi: 10.1016/j.bbr.2012.10.004. Epub 2012 Oct 17. PMID: 23085340 </br>8:The effects of muscimol and AMN082 injections into the medial prefrontal cortex on the expression and extinction of conditioned fear in mice. Morawska MM, Fendt M.J Exp Biol. 2012 Apr 15;215(Pt 8):1394-8. doi: 10.1242/jeb.068213. PMID: 22442378 Free Article</br>9:The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice. Bahi A.Pharmacol Biochem Behav. 2012 Apr;101(2):193-200. doi: 10.1016/j.pbb.2012.01.008. Epub 2012 Jan 16. PMID: 22269296 </br>10:The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling. Bradley SR, Uslaner JM, Flick RB, Lee A, Groover KM, Hutson PH.Pharmacol Biochem Behav. 2012 Mar;101(1):35-40. doi: 10.1016/j.pbb.2011.11.006. Epub 2011 Nov 25. PMID: 22138407 |
