For research use only. Not for therapeutic Use.
Amodiaquine dihydrochloride dihydrate（Cat No.:A000074）is an antimalarial medication belonging to the 4-aminoquinoline class, primarily used for the treatment of malaria, particularly in regions with chloroquine resistance. It functions by inhibiting the heme polymerization process in the malaria parasite, ultimately leading to its death. This compound has shown efficacy against various strains of Plasmodium, including Plasmodium falciparum. Additionally, amodiaquine has demonstrated potential anti-inflammatory properties. Its pharmacokinetic profile and safety make it a valuable option in combination therapies for malaria and highlight its importance in the ongoing fight against this infectious disease.
| Catalog Number | A000074 |
| CAS Number | 6398-98-7 |
| Synonyms | NA |
| Molecular Formula | C20H28Cl3N3O3 |
| Purity | ≥95% |
| Target | Anti-infection |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;dihydrate;dihydrochloride |
| InChI | InChI=1S/C20H22ClN3O.2ClH.2H2O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H;2*1H2 |
| InChIKey | YVNAYSHNIILOJS-UHFFFAOYSA-N |
| SMILES | CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.O.O.Cl.Cl |
| Reference | Sangkuhl, Katrin. /Amodiaquine Pathway, Pharmacokinetics./ PharmGKB. N.p., n.d. Web. 2 Oct. 2013.</span></p> |
