Amonafide

• CAT Number: I004608
• CAS Number: 69408-81-7
• Molecular Formula: C16H17N3O2
• Molecular Weight: 283.33
• Purity: ≥95%
• Synonyms: 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione
• Target: Topoisomerase
• Solubility: DMSO ≥55mg/mL Water <1.2mg/mL Ethanol ≥3.6mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C16H17N3O2.2ClH/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21;;/h3-5,8-9H,6-7,17H2,1-2H3;2*1H
• InChIKey: AEMLYYQEBPJIEO-UHFFFAOYSA-N
• SMILES: O=C1N(CCN(C)C)C(C2=CC(N)=CC3=CC=CC1=C23)=O.[H]Cl.[H]Cl

Amonafide(CAT: I004608) is an anticancer drug belonging to the class of DNA intercalators. It has been used in the treatment of various types of cancer, including acute myeloid leukemia (AML) and breast cancer. Amonafide works by binding to DNA and interfering with its replication and transcription processes, ultimately leading to the inhibition of cancer cell growth. Its mechanism of action involves the inhibition of topoisomerase II, an enzyme involved in DNA replication and repair. However, the use of amonafide has been limited due to its potential side effects, including bone marrow suppression and cardiotoxicity.

Reference

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