For research use only. Not for therapeutic Use.
Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; K<sub>i</sub> = 19 nM and EC<sub>50</sub> = 73 nM) that was first isolated from <em>A. fruticosa.</em> It binds to PPARα and PPARβ/δ with K<sub>i</sub> values of 2.6 and 1.7 µM, respectively. In insulin-resistant mice, 100 mg/kg/day amorfrutin B is reported to improve insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment.
| Catalog Number | R066604 |
| CAS Number | 78916-42-4 |
| Synonyms | 3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)-benzoic acid |
| Molecular Formula | C26H32O4 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Storage | -20°C |
| InChI | InChI=1S/C26H32O4/c1-18(2)9-8-10-19(3)13-16-22-23(30-4)17-21(24(25(22)27)26(28)29)15-14-20-11-6-5-7-12-20/h5-7,9,11-13,17,27H,8,10,14-16H2,1-4H3,(H,28,29)/b19-13+ |
| InChIKey | DKNIJLWIVUCTHW-CPNJWEJPSA-N |
| SMILES | OC(C(C(O)=C(C/C=C(C)/CC/C=C(C)/C)C(OC)=C1)=C1CCC2=CC=CC=C2)=O |
| Reference | 1.Weidner, C.,Wowro, S.J.,Freiwald, A., et al. Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties. Diabetologia 56(8), 1802-1812 (2013). |
